Open AccessWorsening of posterior scleritis and orbital pseudotumor in a patient with granulomatosis polyangiitis with rituximab-A case report
Author(s) -
Kalpana Babu,
BG Dharmanand
Publication year - 2020
Publication title -
indian journal of ophthalmology/indian journal of ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 51
eISSN - 1998-3689
pISSN - 0301-4738
DOI - 10.4103/ijo.ijo_1644_20
Subject(s) - medicine , rituximab , granulomatosis with polyangiitis , scleritis , debulking , exacerbation , prednisolone , episcleritis , surgery , enucleation , dermatology , vasculitis , pathology , ophthalmology , disease , uveitis , lymphoma , ovarian cancer , cancer
We report a case of exacerbation of posterior scleritis and orbital pseudotumor in a patient with granulomatosis polyangiitis, with initial rituximab infusion. Modifications in rituximab protocols including reduction in maintenance dose for subsequent infusions with increase in premedication dose of intravenous methyl prednisolone may be useful to prevent periinfusional flares. In this case report, we highlight a rare occurrence and modification in rituximab protocol to prevent post-infusional flare of inflammation.