Open AccessOcular tuberculosis: Where are we today?
Author(s) -
Ilaria Testi,
Rupesh Agrawal,
Salil Mehta,
Soumvaya Basu,
Quan Dong Nguyen,
Carlos Pavésio,
Vishali Gupta
Publication year - 2020
Publication title -
indian journal of ophthalmology/indian journal of ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 51
eISSN - 1998-3689
pISSN - 0301-4738
DOI - 10.4103/ijo.ijo_1451_20
Subject(s) - tuberculosis , medicine , natural history , disease , intensive care medicine , ocular tuberculosis , clinical practice , pathology , physical therapy
Diagnosis and management of ocular tuberculosis (OTB) poses a significant challenge. Mixed ocular tissue involvement and lack of agreement on best practice diagnostic tests together with the global variations in therapeutic management contributed to the existing uncertainties regarding the outcome of the disease. The current review aims to update recent progress on OTB. In particular, the Collaborative Ocular Tuberculosis Study (COTS) group recently standardized a nomenclature system for defining clinical phenotypes, and also proposed consensus guidelines and an algorithmic approach for management of different clinical phenotypes of OTB. Recent developments in experimental research and innovations in molecular diagnostics and imaging technology have provided a new understanding in the pathogenesis and natural history of the disease.