Open AccessImmunohistochemical and mutational status of telomerase reverse transcriptase in conjunctival squamous cell carcinoma
Author(s) -
Perumal Jayaraj,
Seema Sen,
Kartikey Saxena,
Jassika Gupta,
Pranjal Vats,
Seema Kashyap,
Sheetal Chauhan,
Neelam Pushker
Publication year - 2022
Publication title -
indian journal of ophthalmology/indian journal of ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 51
eISSN - 1998-3689
pISSN - 0301-4738
DOI - 10.4103/ijo.ijo_1342_21
Subject(s) - telomerase reverse transcriptase , immunohistochemistry , medicine , telomerase , pathology , cancer , cell , carcinoma , cancer research , biology , gene , biochemistry , genetics
Mutations in human telomerase reverse transcriptase (TERT) are associated with increased telomerase activity in cutaneous melanomas. Conjunctival squamous cell carcinoma, also referred to as ocular surface squamous cell carcinoma, is cancer on the surface of the eye. Recent studies have identified UV signat`ure mutations in TERT promoters in ocular melanoma and ocular surface squamous neoplasia. However, its immunohistochemical status has not been reported in ocular surface squamous cell carcinoma. This study aimed to explore the immunohistochemical and mutational status of TERT in ocular surface SCC.