Open AccessPrimary membranous glomerulonephritis-associated with schistosomal nephropathy
Author(s) -
Walaa Hosny Mohammad Ibrahim,
Mostafa Aly,
Marwa Kamal Abdo,
Wesam Ismail
Publication year - 2018
Publication title -
indian journal of nephrology/indian journal of nephrology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.317
H-Index - 24
eISSN - 1998-3662
pISSN - 0971-4065
DOI - 10.4103/ijn.ijn_7_18
Subject(s) - medicine , membranous nephropathy , schistosomiasis , antibody , glomerulonephritis , schistosoma mansoni , renal biopsy , pathology , schistosoma , immunology , biopsy , gastroenterology , kidney , helminths
The association of bilharziasis with membranous nephropathy (MN) has long been debated. The relatively recent use of antibodies against the M-type phospholipase A2 receptor (PLA2R) has been proposed as a valuable tool to discriminate the idiopathic from secondary MNs. Anti-PLA2R antibodies are found in sera from about 70% of iMN patients, in contrast to patients with secondary MN, in whom serum anti-PLA2R antibodies could not be detected. In the current case report, we detected anti-PLA2R antibodies both in serum and renal biopsy from a patient with MN associated with Schistosoma mansoni . This finding confirms the idiopathic nature of the MN and excludes schistosomiasis as the triggering agent of MN. After treating bilharziasis, Ponticelli regimen was initiated without a significant improvement.