Open AccessMeasured glomerular filtration rate at dialysis initiation and clinical outcomes of Indian peritoneal dialysis patients
Author(s) -
Narayan Prasad,
Manas Ranjan Patel,
Abhilash Chandra,
Dharshan Rangaswamy,
Archna Sinha,
Dharmendra Bhadauria,
Raj Kumar Sharma,
Anupama Kaul,
Amit Gupta
Publication year - 2017
Publication title -
indian journal of nephrology/indian journal of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.317
H-Index - 24
eISSN - 1998-3662
pISSN - 0971-4065
DOI - 10.4103/ijn.ijn_75_16
Subject(s) - medicine , renal function , peritoneal dialysis , hazard ratio , urology , hemodialysis , dialysis , confidence interval , creatinine , continuous ambulatory peritoneal dialysis , kidney disease , renal replacement therapy
The optimal time for dialysis initiation remains controversial. Studies have failed to show better outcomes with early initiation of hemodialysis; even a few had shown increased adverse outcomes including poorer survival. Few studies have examined the same in patients on peritoneal dialysis (PD). Measured glomerular filtration rate (mGFR) not creatinine-based estimated GFR is recommended as the measure of kidney function in end-stage renal disease (ESRD) patients. The objective of this observational study was to compare the outcomes of Indian patients initiated on PD with different residual renal function (RRF) as measured by 24-h urinary clearance method. A total of 352 incident patients starting on chronic ambulatory PD as the first modality of renal replacement therapy were followed prospectively. Patients were categorized into three groups as per mGFR at the initiation of PD (≤5, >5-10, and >10 ml/min/1.73 m 2 ). Patient survival and technique survival were compared among the three groups. Patients with GFR of ≤5 ml/min/1.73 m 2 (hazard ratio [HR] - 3.42, 95% confidence interval [CI] - 1.85-6.30, P = 0.000) and >5-10 ml/min/1.73 m 2 (HR - 2.16, 95% CI - 1.26-3.71, P = 0.005) had higher risk of mortality as compared to those with GFR of >10 ml/min/1.73 m 2 . Each increment of 1 ml/min/1.73 m 2 in baseline GFR was associated with 10% reduced risk of death (HR - 0.90, 95% CI - 0.85-0.96, P = 0.002). Technique survival was poor in those with an initial mGFR of ≤5 ml/min/1.73 m 2 as compared to other categories. RRF at the initiation was also an important factor predicting nutritional status at 1 year of follow-up. To conclude, initiation of PD at a lower baseline mGFR is associated with poorer patient and technique survival in Indian ESRD patients.