Open AccessEffect of vitamin D on urinary angiotensinogen level in early diabetic nephropathy
Author(s) -
Himansu Sekhar Mahapatra,
Adarsh Kumar,
Bindu Kulshreshtha,
Anubhuti Chitkara,
Anamika Kumari
Publication year - 2021
Publication title -
indian journal of nephrology/indian journal of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.317
H-Index - 24
eISSN - 1998-3662
pISSN - 0971-4065
DOI - 10.4103/ijn.ijn_67_20
Subject(s) - medicine , vitamin d and neurology , cholecalciferol , endocrinology , placebo , interquartile range , urinary system , creatinine , diabetic nephropathy , vitamin , renal function , urology , kidney , pathology , alternative medicine
Urinary angiotensinogen (UAGT) is supposed to be a marker of activation of the intrarenal renin- angiotensin system (RAS) system in early diabetic nnephropathy (EDN). Vitamin D has been studied as a negative regulator of the circulating and tissue RAS activity, so its supplementation may prevent the progression of diabetic nephropathy (DN). This study was planned to assess the RAS activation and effect of vitamin D supplementation in EDN progression by estimating the UAGT level.