Open AccessBladder carcinoma associated with BK virus in a renal allograft recipient
Author(s) -
Lovy Gaur,
Ashwani Gupta,
Priti Meena,
Aakash Shingada,
Pallav Gupta,
Devinder Singh Rana
Publication year - 2019
Publication title -
indian journal of nephrology/indian journal of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.317
H-Index - 24
eISSN - 1998-3662
pISSN - 0971-4065
DOI - 10.4103/ijn.ijn_434_17
Subject(s) - bk virus , urothelium , medicine , virus , carcinogenesis , pathogenesis , pathology , carcinoma , polyomavirus infections , cancer research , kidney , virology , urinary bladder , cancer , kidney transplantation
Bladder carcinoma is a relatively rare carcinoma reported in renal allograft recipients. While many oncogenic viruses have been implicated as causative factors for certain malignancies, questions have been raised about possible role of BK virus in pathogenesis of urothelial cancers. In this report, we have described a patient who developed BK virus nephropathy followed 3 years later by bladder carcinoma. Interestingly, while the tumor tissue demonstrated BK virus, the adjacent normal urothelium was stained negative for BK virus. Considering the viral potential to inhibit tumor suppressors and its differential localization within tumor tissue, it is possible that the virus contributes to tumorigenesis.