Open AccessCryptococcal infection in transplant kidney manifesting as chronic allograft dysfunction
Author(s) -
Chandra Shekhar Agrawal,
Vivek Sood,
Amit Kumar,
Vasudevan A. Raghavan
Publication year - 2017
Publication title -
indian journal of nephrology/indian journal of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.317
H-Index - 24
eISSN - 1998-3662
pISSN - 0971-4065
DOI - 10.4103/ijn.ijn_298_16
Subject(s) - medicine , subclinical infection , incidence (geometry) , urinary system , cryptococcus , bone marrow transplant , kidney transplantation , lung , immunology , kidney , transplantation , bone marrow transplantation , physics , microbiology and biotechnology , optics , biology
Invasive fungal infections (IFIs) are a significant cause of morbidity in solid organ transplant (SOT) recipients. Common causes among them are Aspergillus , Candida , and Cryptococcus . Antifungal prophylaxis has led to decrease in overall incidence of IFI; however, there is very little decline in the incidence of Cryptococcal infections of SOT recipients because effective prophylaxis is not available against this infectious agent. Spectrum of manifestation of Cryptococcal infection varies in immunocompetent and immunocompromised host with subclinical and self-limiting with lungs being the primary site in immunocompetent and central nervous system as the most common site in an immunocompromised host. Other preferred sites are cutaneous, pulmonary, urinary tract (prostate) and the bone. Herein, we describe a young adult renal transplant recipient male diagnosed as a rare case of biopsy proven Cryptococcal infection in transplant kidney manifesting as chronic allograft dysfunction.