Open AccessIgA nephropathy with wilson's disease: A case report and literature review
Author(s) -
Gaurav Bhandari,
V. Tiwari,
Anurag Gupta,
Pallav Gupta,
Vinant Bhargava,
Manish Malik,
Ashwani Gupta,
Anil Kumar Bhalla,
Devinder Singh Rana
Publication year - 2021
Publication title -
indian journal of nephrology/indian journal of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.317
H-Index - 24
eISSN - 1998-3662
pISSN - 0971-4065
DOI - 10.4103/ijn.ijn_227_20
Subject(s) - medicine , proteinuria , renal biopsy , nephropathy , glomerulonephritis , gastroenterology , pathology , microscopic hematuria , liver biopsy , urinary system , biopsy , kidney , endocrinology , diabetes mellitus
The most common glomerulonephritis seen in the world is immunoglobulin A nephropathy (IgAN). It can be primary or secondary associated with various conditions like Chronic Liver disease, Crohn's disease, neoplasms, etc. However, IgAN secondary to Wilson's disease is very rare. A 9 year old boy presented with gross hematuria and proteinuria. He had a history of recurrent jaundice in the past. Ultrasonography (USG) whole abdomen showed altered echotexture of the liver with normal-sized kidneys. An extended workup for liver disease was done, and the diagnosis of Wilson's disease was confirmed with decreased serum ceruloplasmin levels, increased urinary copper, and the Kayser-Fleischer ring. Urine routine microscopy showed numerous red blood cells, few red blood cell casts, and mild proteinuria. Renal biopsy showed IgAN. The patient was started on D-penicillamine. On follow-up at 3 months, he showed complete resolution of proteinuria and hematuria. Thus, we suggest that Wilson's disease should be considered as one of the causes of secondary IgAN in pediatric patients with hematuria, proteinuria with liver dysfunction.