Open AccessType I cryoglobulinemic nephritis in a patient of monoclonal gammopathy of renal significance
Author(s) -
Valentine Lobo,
Kuttichantran Subramaniam,
MA Bidaye,
Shayu Deshpande
Publication year - 2018
Publication title -
indian journal of nephrology/indian journal of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.317
H-Index - 24
eISSN - 1998-3662
pISSN - 0971-4065
DOI - 10.4103/ijn.ijn_175_16
Subject(s) - medicine , clone (java method) , monoclonal gammopathy of undetermined significance , monoclonal , monoclonal gammopathy , nephritis , renal biopsy , pathology , multiple myeloma , glomerulonephritis , bone marrow , monoclonal antibody , biopsy , immunology , kidney , antibody , biology , dna , genetics
Monoclonal gammopathy of renal significance is a recently described entity in which a small B-cell clone not meeting the criteria for the diagnosis of multiple myeloma produces renal disease usually through deposition of a secreted monoclonal immunoglobulin. Here, we describe a case of Type I cryoglobulinemic glomerulonephritis diagnosed on a kidney biopsy and caused by a monoclonal IgM produced by a small bone marrow clone. The patient made a complete renal recovery after chemotherapy to suppress the clone.