Open AccessDense deposit disease involving C3 and C4d Deposits
Author(s) -
Mahesha Vankalakunti,
Rohan Augustine,
Ravi Jangamani,
Vishwanath Siddini,
Ravishankar Bonu,
Kishore Babu,
SH Ballal
Publication year - 2018
Publication title -
indian journal of nephrology/indian journal of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.317
H-Index - 24
eISSN - 1998-3662
pISSN - 0971-4065
DOI - 10.4103/ijn.ijn_164_16
Subject(s) - membranoproliferative glomerulonephritis , lamina densa , medicine , disease , glomerular basement membrane , basement membrane , pathology , glomerulonephritis , kidney
Dense deposit disease (DDD), earlier called Type II membranoproliferative glomerulonephritis is distinct disease having frequent relapses reaching end-stage kidney disease by 10-year in up to 50%-60% of cases and high recurrence rate in the allograft. The term DDD is derived from its distinctive ribbon-like osmiophilic deposits in the lamina densa of glomerular basement membrane by electron microscopy. Pathogenetically, alternate pathway dysfunction leads to this disease, which is diagnosed by ultrastructure. Herein, we describe our observation of C4d positivity in an adolescent boy with DDD.