Open AccessCirculating monoclonal IgG1-kappa antibodies causing anti-glomerular basement membrane nephritis
Author(s) -
Mahesha Vankalakunti,
Ritambhra Nada,
Ashwani Kumar,
Kanhu Charan Patro,
S Ramakrishnan,
Dilip Rangarajan
Publication year - 2017
Publication title -
indian journal of nephrology/indian journal of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.317
H-Index - 24
eISSN - 1998-3662
pISSN - 0971-4065
DOI - 10.4103/ijn.ijn_113_16
Subject(s) - medicine , glomerular basement membrane , nephritis , monoclonal antibody , plasmapheresis , polyclonal antibodies , pulmonary hemorrhage , immunosuppression , rapidly progressive glomerulonephritis , basement membrane , antibody , pathology , monoclonal , glomerulonephritis , immunology , disease , kidney , vasculitis , lung
Anti-glomerular basement membrane (GBM) antibody disease is a rare but well-characterized cause of glomerulonephritis. Patients present with rapidly progressive renal failure with hemoptysis. Early diagnosis is crucial in salvaging the renal damage and life-threatening pulmonary hemorrhage. Plasmapheresis and immunosuppression is the mode of therapy. Anti-GBM antibodies are polyclonal in nature. However, rare monoclonal antibodies can cause similar destruction of glomerular capillary walls. We describe distinct combination of circulating monoclonal and anti-GBM nephritis.