Open AccessDiagnostic Utility of GenoType MTBDRsl Assay for the Detection of Moxifloxacin-Resistant Mycobacterium tuberculosis, as Compared to Phenotypic Method and Whole-Genome Sequencing
Author(s) -
R. N. S. Yadav,
Manpreet Bhalla,
Gavish Kumar,
Grish C. Sah,
Ravindra Kumar Dewan,
Ritu Singhal
Publication year - 2022
Publication title -
international journal of mycobacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 20
eISSN - 2212-554X
pISSN - 2212-5531
DOI - 10.4103/ijmy.ijmy_70_22
Subject(s) - mycobacterium tuberculosis , genotype , moxifloxacin , sputum , tuberculosis , biology , microbiology and biotechnology , mycobacterium tuberculosis complex , mycobacterium , bacteria , genetics , medicine , gene , antibiotics , pathology
Recently, moxifloxacin (MFX)-resistant results of Mycobacterium tuberculosis (Mtb) obtained by GenoType MTBDRsl (second-line line probe assay [SL-LPA]) have been stratified to determine their resistance level; however, its accuracy has not been well studied. Therefore, the study aimed to evaluate the diagnostic accuracy of SL-LPA, with phenotypic drug susceptibility testing (pDST) and whole-genome sequencing (WGS) for the detection of MFX-resistant Mtb and their resistance level.
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