Open AccessAssessing the susceptibility of highly pathogenic avian influenza H5N1 viruses to oseltamivir using embryonated chicken eggs
Author(s) -
Deeksha S. Tare,
Sadhana S. Kode,
Aeron C. Hurt,
Shailesh D. Pawar
Publication year - 2019
Publication title -
indian journal of medical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.578
H-Index - 87
ISSN - 0971-5916
DOI - 10.4103/ijmr.ijmr_845_18
Subject(s) - embryonated , virology , influenza a virus subtype h5n1 , oseltamivir , biology , in ovo , neuraminidase , microbiology and biotechnology , infectious dose , virus , neuraminidase inhibitor , medicine , infectious disease (medical specialty) , embryo , disease , covid-19 , pathology
The susceptibility of influenza viruses to neuraminidase inhibitors (NAIs) is studied using enzyme-based assays, sequence analysis and in vitro and in vivo studies. Oseltamivir carboxylate (OC) is the active prodrug of the NAI oseltamivir. There is lack of information on the use of embryonated chicken eggs for studying susceptibility of highly pathogenic avian influenza (HPAI) H5N1 viruses to antiviral drugs. The aim of the present study was to assess the use of 10 day old embryonated chicken eggs for studying antiviral susceptibility of HPAI H5N1 viruses.