Open AccessAspirin & clopidogrel non-responsiveness & its association with genetic polymorphisms in patients with myocardial infarction
Author(s) -
Chandra Prakash Pandey,
Aalok Misra,
Mahendra Pal Singh Negi,
Babunageswararao Kanuri,
Yashpal S. Chhonker,
Rabi Shanker Bhatta,
V.S. Narain,
Madhu Dikshit
Publication year - 2019
Publication title -
indian journal of medical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.578
H-Index - 87
ISSN - 0971-5916
DOI - 10.4103/ijmr.ijmr_782_17
Subject(s) - clopidogrel , aspirin , medicine , cyp2c19 , odds ratio , p2y12 , myocardial infarction , adenosine diphosphate , platelet , confidence interval , platelet activation , cardiology , pharmacology , gastroenterology , cytochrome p450 , platelet aggregation , metabolism
Cytochrome P450, P2Y 12, cyclooxygenase-1 (COX1) and glycoprotein V1 (GPVI) gene polymorphisms are known to affect patient responsiveness towards aspirin and clopidogrel dual antiplatelet therapy (DAPT). The present study was undertaken to identify aspirin and clopidogrel non-responsiveness and its association with genetic polymorphism in patients with myocardial infarction (MI).