Open AccessIdentification & characterization of leucine-rich repeat kinase 2 & parkin RBR E3 ubiquitin protein ligase variants in patients with Parkinson's disease
Author(s) -
Tamali Halder,
Swati Verma,
Janak Raj,
Sharad Pandey,
Ranjeet Singh,
Vivek Sharma,
Deepika Joshi,
Parimal Das
Publication year - 2020
Publication title -
indian journal of medical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.578
H-Index - 87
ISSN - 0971-5916
DOI - 10.4103/ijmr.ijmr_730_18
Subject(s) - missense mutation , in silico , lrrk2 , parkin , exon , genetics , ubiquitin ligase , biology , gene , dna ligase , mutation , microbiology and biotechnology , medicine , disease , parkinson's disease , ubiquitin
Parkinson's disease (PD) is a motor disorder that affects movement. More than 24 loci and 28 associated genes have been identified to be associated with this disease. The present study accounts for the contribution of two candidates, leucine-rich repeat kinase 2 ( LRRK2) and parkin RBR E3 ubiquitin protein ligase ( PRKN) in the PD patients, and their characterization in silico and in vitro.