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Oral squamous cell carcinoma is one of the most lethal forms of cancer, and its aetiology has been attributed to both genetic and epigenetic factors working in liaison to contribute to the disease. Epigenetic changes especially DNA methylation is involved in the activation or repression of gene functions. The aim of this study was to investigate the DNA methylation pattern and expression profiling of the promoter regions of FMS-related tyrosine kinase 3 (FLT3), erythrocyte membrane protein band 4.1-like 3 (EPB41L3) and stratifin (SFN) genes in oral cancer within the Khasi and Jaintia tribal population of Meghalaya in North East India.

the indian journal of medical research

Promoter-associated DNA methylation &amp; expression profiling of genes (FLT 3, EPB41L3 &amp; SFN) in patients with oral squamous cell carcinoma in the Khasi &amp; Jaintia population of Meghalaya, India