Open AccessAssociation of increased risk of asthma with elevated arginase & interleukin-13 levels in serum & rs2781666 G/T genotype of arginase I
Author(s) -
Suhasini Donthi,
Venkata Sanjeev Kumar Neela,
Sumanlatha Gaddam,
Hidayath Hussain Mohammed,
Soheb Sadath Ansari,
Vijaya Lakshmi Valluri,
K. S. R. Sivasai
Publication year - 2018
Publication title -
indian journal of medical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.578
H-Index - 87
ISSN - 0971-5916
DOI - 10.4103/ijmr.ijmr_379_16
Subject(s) - arginase , asthma , single nucleotide polymorphism , genotype , immunology , medicine , allergy , endocrinology , biology , gene , genetics , amino acid , arginine
High expression of arginase gene and its elevated level in serum and bronchial lavage reported in animal models indicated an association with the pathogenesis of asthma. This study was undertaken to assess the serum arginase activity in symptomatic asthma patients and healthy controls and to correlate it with cytokine levels [interleukin (IL)-4 and IL-13] and arginase I (ARG1) gene polymorphism.