Open AccessAdhesion molecules facilitate host-pathogen interaction & mediate Mycobacterium tuberculosis pathogenesis
Author(s) -
Durga Bisht,
Laxman S. Meena
Publication year - 2019
Publication title -
indian journal of medical research
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.578
H-Index - 87
ISSN - 0971-5916
DOI - 10.4103/ijmr.ijmr_2055_16
Subject(s) - cell adhesion molecule , immune system , biology , host (biology) , microbiology and biotechnology , cell adhesion , adhesion , mycobacterium tuberculosis , receptor , pathogen , host–pathogen interaction , cell , tuberculosis , immunology , chemistry , virulence , genetics , medicine , gene , organic chemistry , pathology
Most of the microorganisms display adhesion molecules on their surface which help them to bind and interact with the host cell during infection. Adhesion molecules help mycobacteria to colonize and invade immune system of the host, and also trigger immune response explicated by the host against the infection. Hence, understanding the signalling pathways illustrated by these molecules to enhance our knowledge on mycobacterial survival and persistence inside the host cell is required. Hence, this review was focussed on the role of adhesion molecules and their receptor molecules. The various mechanisms adopted by adhesion molecules to bind with the specific receptors on the host cell and their role in invasion and persistence of mycobacterium inside the host cell are explained.