Open AccessGenotype-phenotype relationship of CCL5 in pulmonary tuberculosis infection in Sahariya tribe: A pilot study
Author(s) -
Govind Mishra,
Satish S. Poojary,
Sanjay Jain,
Pramod Kumar Tiwari
Publication year - 2017
Publication title -
indian journal of medical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.578
H-Index - 87
ISSN - 0971-5916
DOI - 10.4103/ijmr.ijmr_1582_15
Subject(s) - genotype , sputum , tuberculosis , snp , single nucleotide polymorphism , mycobacterium tuberculosis , medicine , immunology , biology , genetics , gene , pathology
Sahariya, a primitive tribe of Central India, has shown significantly increased incidence of pulmonary tuberculosis (PTB). Our previous study on Sahariya showed a significant association of -403G>A single nucleotide polymorphism (SNP) of CCL5 with susceptibility to PTB. Hence, this study was aimed to analyze a genotype-phenotype relationship of this disease-associated SNP to develop a potential diagnostic marker for TB in this tribe.