Open AccessNeuroprotective effect of Cubebin: A dibenzylbutyrolactone lignan on scopolamine-induced amnesia in mice
Author(s) -
Gauresh Somani,
Mruniya S Nahire,
Aakash D Parikh,
Mandar B Mulik,
Priya Ghumatkar,
K. S. Laddha,
Sadhana Sathaye
Publication year - 2017
Publication title -
indian journal of medical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.578
H-Index - 87
ISSN - 0971-5916
DOI - 10.4103/ijmr.ijmr_156_14
Subject(s) - acetylcholinesterase , aché , morris water navigation task , oxidative stress , pharmacology , chemistry , cholinergic , neuroprotection , antioxidant , memory impairment , biochemistry , medicine , endocrinology , enzyme , psychology , neuroscience , hippocampus , cognition
Acetylcholinesterase (AChE) inhibitors represent a major class of drugs which provide symptomatic relief and improvement in cognitive function in Alzheimer's disease (AD). In this study, cubebin, a dibenzylbutyrolactone lignan, was isolated from Piper cubeba and investigated for its AChE inhibitory activity in an attempt to explore its potential for memory-enhancing activities in mice.