Open AccessPathogenic gene expression of epicardial adipose tissue in patients with coronary artery disease
Author(s) -
Anagha Sahasrabuddhe,
Shailesh Pitale,
Saravana Devi Sivanesan,
Purushottam Deshpande,
Swapnil P Deshpande,
Atul P. Daiwile
Publication year - 2020
Publication title -
indian journal of medical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.578
H-Index - 87
ISSN - 0971-5916
DOI - 10.4103/ijmr.ijmr_1374_18
Subject(s) - medicine , coronary artery disease , adiponectin , adipose tissue , leptin , odds ratio , endocrinology , cardiology , artery , insulin resistance , insulin , obesity
Coronary artery disease (CAD), a leading cause of mortality and morbidity worldwide has multifactorial origin. Epicardial adipose tissue (EAT) has complex mechanical and thermogenic functions and paracrine actions via various cytokines released by it, which can have both pro- and anti-inflammatory actions on myocardium and adjacent coronaries. The alteration of EAT gene expression in CAD is speculated, but poorly understood. This study was undertaken to find out the difference in gene expression of epicardial fat in CAD and non-CAD patients.