Open AccessPredictive power of tumour budding for lymph node metastasis in colorectal carcinomas: A retrospective study
Author(s) -
Brototo Deb,
Sajini Elizabeth Jacob
Publication year - 2019
Publication title -
indian journal of medical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.578
H-Index - 87
ISSN - 0971-5916
DOI - 10.4103/ijmr.ijmr_1268_17
Subject(s) - budding , lymphovascular invasion , tumor budding , colorectal cancer , pathology , medicine , metastasis , lymph node , biopsy , lymph node metastasis , cancer , biology , genetics
Tumour budding is a feature of epithelial-to-mesenchymal transformation that is characterized histologically within the tumour stroma by the presence of isolated cells or clusters of less than five cells which are different from the other malignant cells. This could be present around the invasive margin of the tumour, called peritumoural budding, or in the bulk of the tumour, called intratumoural budding. The aim of this study was to assess the predictive power of tumour budding for lymph node metastasis and its relationship with other features of tumour progression in colorectal carcinoma (CRC).