Open AccessTherapeutic potential of xanthones from Swertia chirata in breast cancer cells
Author(s) -
Atish Barua,
Pritha Choudhury,
Suvra Mandal,
Chinmay Kumar Panda,
Prosenjit Saha
Publication year - 2020
Publication title -
indian journal of medical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.578
H-Index - 87
ISSN - 0971-5916
DOI - 10.4103/ijmr.ijmr_1153_18
Subject(s) - in vivo , ehrlich ascites carcinoma , comet assay , chemistry , superoxide dismutase , cytotoxicity , lipid peroxidation , dna fragmentation , dna damage , microbiology and biotechnology , apoptosis , pharmacology , biochemistry , biology , in vitro , programmed cell death , antioxidant , dna
Medicinal plants like Swertia chirata are rich sources of different xanthones. This study was aimed to assess the cytotoxic potential of four most abundant xanthones present in S. chirata both in vivo and in vitro in Ehrlich ascites carcinoma (EAC), a mouse transplantable breast carcinoma cell line and two human breast carcinoma cell lines (MCF-7 and MDA-MB-231).