Open AccessMitochondrial DNA content of peripheral blood mononuclear cells in ART untreated & stavudine/zidovudine treated HIV-1-infected patients
Author(s) -
Dhakshinamoorthy Subashini,
Thongadi Ramesh Dinesha,
Rao B. Srirama,
Jayaseelan Boobalan,
Selvamuthu Poongulali,
Devaraj A. Chitra,
S. N. Mothi,
Sunil S. Solomon,
S. Saravanan,
Suniti Solomon,
Pachamuthu Balakrishnan
Publication year - 2018
Publication title -
indian journal of medical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.578
H-Index - 87
ISSN - 0971-5916
DOI - 10.4103/ijmr.ijmr_1144_16
Subject(s) - stavudine , zidovudine , mitochondrial toxicity , peripheral blood mononuclear cell , mitochondrial dna , asymptomatic , toxicity , virology , reverse transcriptase inhibitor , mitochondrion , medicine , didanosine , immunology , biology , viral load , virus , viral disease , antiretroviral therapy , in vitro , biochemistry , gene , microbiology and biotechnology
Nucleoside reverse transcriptase inhibitors (NRTIs) are known to cause mitochondrial toxicity. This study was done to estimate mitochondrial DNA (mtDNA) content of peripheral blood mononuclear cells (PBMCs) among human immunodeficiency virus (HIV) infected, NRTI treated and antiretroviral therapy (ART)-naïve patients and evaluate the utility of mtDNA content as a biomarker of mitochondrial toxicity.