Open AccessMethotrexate and mucositis: A merry-go-round for oncologists
Author(s) -
Kundan Mishra,
Aditya Jandial,
Anil Kumar,
Deepesh Lad,
Gaurav Prakash,
Alka Khadwal,
Pankaj Malhotra
Publication year - 2019
Publication title -
indian journal of medical and paediatric oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.229
H-Index - 22
eISSN - 0975-2129
pISSN - 0971-5851
DOI - 10.4103/ijmpo.ijmpo_113_18
Subject(s) - mucositis , medicine , methotrexate , folinic acid , gastroenterology , chemotherapy , fluorouracil
High-dose methotrexate is the backbone of various regimens for treating lymphoid malignancies. Mucositis is a well-known, dose-related side effect of methotrexate. Prophylactic measures such as folinic acid rescue are useful but do not prevent mucositis in all the cases. Once severe mucositis (WHO Grade IV) sets in, mortality is very high. The index case highlights the natural course of methotrexate-induced mucositis and the need for swift and preemptive intervention.