Open AccessMutational profile of papillary thyroid carcinoma in an endemic goiter region of North India
Author(s) -
Nelson George,
Amit Agarwal,
Niraj Kumari,
Sarita Agarwal,
Narendra Krisnani,
Sushil K. Gupta
Publication year - 2018
Publication title -
indian journal of endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.456
H-Index - 28
eISSN - 2230-9500
pISSN - 2230-8210
DOI - 10.4103/ijem.ijem_441_17
Subject(s) - thyroid carcinoma , v600e , cancer research , papillary thyroid cancer , medicine , sanger sequencing , goiter , metastasis , mutation , concomitant , thyroid cancer , gene , thyroid , biology , cancer , genetics
Mitogen activated protein kinase (MAPK) pathway is regularly altered in papillary thyroid carcinomas (PTCs). Serine/threonine-protein kinase B-Raf (BRAF) V600E mutations were observed very frequently in PTC along with less frequent rat sarcoma (RAS) and rearranged during transfection (RET) gene, also known as RET/PTC translocation. The present study aimed to analyze the mutational profile of PTCs from an endemic Goiter area of North India.