Open AccessLack of association of B-type raf kinase V600E mutation with high-risk tumor features and adverse outcome in conventional and follicular variants of papillary thyroid carcinoma
Author(s) -
C. Gopalakrishnan Nair,
Merin Babu,
Lalitha Biswas,
Pradeep Jacob,
Riju Ramachandran,
A.K. Revathy,
Krishnanunni Nair
Publication year - 2017
Publication title -
indian journal of endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.456
H-Index - 28
eISSN - 2230-9500
pISSN - 2230-8210
DOI - 10.4103/ijem.ijem_353_16
Subject(s) - medicine , thyroid carcinoma , mutation , oncology , follicular phase , cancer research , thyroid , gene , genetics , biology
Somatic B-type Raf kinase (BRAF) V600E mutation in exon 15 was frequently found in high frequencies associated with papillary thyroid cancer (PTC). The phenotype of these cancers expressed aggressive clinical and pathological features. The present study aimed to assess the prevalence of BRAF V600E mutation among conventional and follicular variants of PTC and its association with aggressive tumor factors and outcome.