Open AccessOptimizing cord blood thyroid stimulating hormone cutoff for screening of congenital hypothyroidism—experience from screening 164,000 newborns in a tertiary hospital in India
Author(s) -
Sarah Mathai,
PraveenG Paul,
Grace Rebekah,
Sophy Korula,
Manish Kumar,
JosephD Bondu,
P. Raghupathy,
Anna Simon
Publication year - 2021
Publication title -
indian journal of endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.456
H-Index - 28
eISSN - 2230-9500
pISSN - 2230-8210
DOI - 10.4103/ijem.ijem_220_21
Subject(s) - medicine , congenital hypothyroidism , cutoff , thyroid stimulating hormone , thyroid , newborn screening , cord blood , pediatrics , gastroenterology , physics , quantum mechanics
In our institution, we have an ongoing newborn thyroid screening (NBS) program since July 2001. In the initial 9 months, we used cord blood thyroid-stimulating hormone (TSH) (CBTSH) cutoff of 20 mIU/L and thereafter the cutoff was increased to 25 mIU/L. Our objective was to evaluate whether a CBTSH cutoff of 25 mIU/L is sensitive and cost-effective in NBS of congenital hypothyroidism (CH).