Open AccessValidation and clinical application of interferon-gamma release assay for diagnosis of latent tuberculosis infection in children
Author(s) -
Kirtilaxmi Benachinmardi,
S. Sangeetha,
M. P. Rao,
R Prema
Publication year - 2019
Publication title -
international journal of applied and basic medical research/international journal of applied and basic medical research
Language(s) - English
Resource type - Journals
eISSN - 2248-9606
pISSN - 2229-516X
DOI - 10.4103/ijabmr.ijabmr_86_19
Subject(s) - tuberculin , medicine , latent tuberculosis , interferon gamma release assay , tuberculosis , asymptomatic , incidence (geometry) , interferon γ , confidence interval , mycobacterium tuberculosis , interferon gamma , immunology , pathology , cytokine , physics , optics
India has the highest tuberculosis (TB) burden, accounting for one-fifth of the global incidence and two-third of the cases in Southeast Asia with an estimated 1.9 million new cases every year. Identifying and treating latent TB infection (LTBI) can reduce the risk of development of active disease by up to 90%, thereby decreasing a major burden to the prevalence of the disease, and thus reducing potential sources in future.