Open AccessRetinoic acid embryopathy
Author(s) -
Dodul Mondal,
Sreekanth R Shenoy,
Santisena Mishra
Publication year - 2017
Publication title -
international journal of applied and basic medical research/international journal of applied and basic medical research
Language(s) - English
Resource type - Journals
eISSN - 2248-9606
pISSN - 2229-516X
DOI - 10.4103/ijabmr.ijabmr_469_16
Subject(s) - craniofacial , isotretinoin , medicine , retinoid , microtia , retinoic acid , teratology , pregnancy , physiology , dermatology , fetus , acne , anatomy , biology , genetics , psychiatry , gene
Isotretinoin is a retinoid which is derived from Vitamin A. It is indicated for severe cystic acne treatment, but it has been classified as teratogenic. A wide spectrum of birth defects including craniofacial, heart, and nervous system malformations have been described with prenatal exposure to this drug. We report the case of a newborn with a history of prenatal exposure to isotretinoin with craniofacial defects, including left-sided anotia, right-sided microtia, complex congenital heart disease, and central nervous system malformation.