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Anxiety causing stress is most profound before surgery. Anxiolytics are used routinely to combat perioperative anxiety. Studies have shown that hand-holding and communication are useful in reducing anxiety levels intraoperatively. This study compares the effectiveness of the same with pharmacological interventions in allaying preoperative anxiety.

Effect of hand-holding and conversation alone or with midazolam premedication on preoperative anxiety in adult patients—A randomised controlled trial