Open AccessTo evaluate the role and relevance of cytokines IL-17, IL-18, IL-23 and TNF-α and their correlation with disease severity in chronic urticaria
Author(s) -
Preeti Sharma,
Praffula K Sharma,
Anubhuti Chitkara,
Seema Rani
Publication year - 2020
Publication title -
indian dermatology online journal
Language(s) - English
Resource type - Journals
eISSN - 2249-5673
pISSN - 2229-5178
DOI - 10.4103/idoj.idoj_396_19
Subject(s) - medicine , chronic urticaria , tumor necrosis factor alpha , pathogenesis , interleukin , clinical significance , immunology , disease , cytokine , correlation , interleukin 6 , gastroenterology , geometry , mathematics
The basic event in the pathogenesis of urticaria is inappropriate activation and degranulation of dermal mast cells. Cytokines are soluble polypeptide mediators that play a key role in immunological, inflammatory and reparative host responses including chronic urticaria.