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Oral submucous fibrosis (OSMF) caused by dense deposition of collagen fibers which is a protein. There is a plethora of research to evaluate degree of collagen deposition using various simple histochemical techniques, but its correlation with total serum protein (TSP) level has not been explored so far.

contemporary clinical dentistry

Total serum protein estimation and its correlation with clinical and histopathological grading using Masson's Trichrome stain in patients of oral submucous fibrosis