Open AccessMeta-analysis of risk association between interleukin-17a gene polymorphism and chronic periodontitis
Author(s) -
Priyanka Sasikumar,
Sheeja Varghese,
Thanga Kumaran,
Sakthi Saranya Devi
Publication year - 2020
Publication title -
contemporary clinical dentistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.289
H-Index - 21
eISSN - 0976-237X
pISSN - 0976-2361
DOI - 10.4103/ccd.ccd_448_19
Subject(s) - chronic periodontitis , periodontitis , interleukin 17 , meta analysis , medicine , aggressive periodontitis , interleukin , immunology , gene polymorphism , polymorphism (computer science) , inflammation , genetic association , pooling , cytokine , allele , gene , genetics , genotype , single nucleotide polymorphism , biology , computer science , artificial intelligence
The association of genetic polymorphisms with periodontitis has been studied extensively. The interleukin-7 (IL-17) is a group of cytokines, which comprises six different molecules (IL-17A, B, C, D, E, and F). Among this, IL-17A is the most commonly understood cytokine, and its polymorphism plays a critical role in inflammatory diseases and periodontal inflammation. The present study was aimed at pooling the data available for meta-analysis and to evaluate whether IL-17A (rs2275913) polymorphism is associated with the susceptibility of chronic periodontitis.