Open AccessFatal rapidly progressive interstitial lung disease in a patient with amyopathic dermatomyositis
Author(s) -
Abdullah F. Mobeireek,
Walter Conca,
Shamayel Mohammed,
Fahad Alobaid,
Ahmed Mohammed
Publication year - 2021
Publication title -
annals of thoracic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.639
H-Index - 33
eISSN - 1817-1737
pISSN - 1998-3557
DOI - 10.4103/atm.atm_739_20
Subject(s) - medicine , dermatomyositis , interstitial lung disease , proximal muscle weakness , creatine kinase , dermatology , lung , disease , incidence (geometry) , refractory (planetary science) , pathology , muscle biopsy , biopsy , astrobiology , optics , physics
Interstitial lung disease (ILD) is a well-established common manifestation of idiopathic inflammatory myopathies. Yet, till now, the pathogenetic mechanisms are still poorly understood, classification is evolving and prognosis is variable. A refractory and rapidly progressive ILD (RPILD) that is associated with dermatomyositis (DM) with minimal muscle weakness and normal creatine kinase (termed clinically amyopathic DM) is increasingly being recognized, with more incidence in Asians. However, we are not aware of reports of the Arab region. Herein, we present a 38-year-old male with this condition that ended with a fatal outcome despite aggressive therapy, with a review of recent literature.