z-logo
open-access-imgOpen Access
Steroid-associated bradycardia in a newly diagnosed B precursor acute lymphoblastic leukemia patient with Holt–Oram syndrome
Author(s) -
Raymond Morales,
Bishir Clayton,
Hoang H. Nguyen,
Lisa Giordano,
Brieann Muller
Publication year - 2020
Publication title -
annals of pediatric cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.292
H-Index - 19
eISSN - 0974-2069
pISSN - 0974-5149
DOI - 10.4103/apc.apc_87_19
Subject(s) - medicine , lymphoblastic leukemia , bradycardia , pediatrics , leukemia , heart rate , blood pressure
Holt-Oram syndrome (HOS) (OMIM#142900) is a rare condition with upper extremity malformations as well as structural and conduction cardiac anomalies. There are sparse reports in the literature documenting malignancy in association with HOS. We report a pediatric patient clinically diagnosed with HOS (missing thumbs bilaterally, atrial septal defect, ventricular septal defect, and first-degree heart block), who also developed B precursor acute lymphoblastic leukemia. During induction of chemotherapy with steroids, she developed profound bradycardia without clinical symptoms. The bradycardia resolved without intervention, but this case highlights the challenges of managing chemotherapy side effects in a patient with congenital heart disease. A literature review pertinent to the associated findings in the case is also presented.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.
Having issues? You can contact us here