Open AccessN-terminal-pro-b-type natriuretic peptide levels and cardiac hemosiderosis in adolescent β-thalassemia major patients
Author(s) -
Ahmad Kautsar,
Najib Advani,
Murti Andriastuti
Publication year - 2019
Publication title -
annals of pediatric cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.292
H-Index - 19
eISSN - 0974-2069
pISSN - 0974-5149
DOI - 10.4103/apc.apc_49_18
Subject(s) - medicine , hemosiderosis , natriuretic peptide , thalassemia , terminal (telecommunication) , cardiology , heart failure , telecommunications , computer science
Iron-induced cardiomyopathy remains the leading cause of mortality in patients with β-thalassemia major. Iron overload cardiomyopathy, which may be reversible through iron chelation, is characterized by early diastolic dysfunction. Amino-terminal pro-brain natriuretic peptide (NT-proBNP) is a sensitive biomarker of diastolic dysfunction.