Open Accessİnvestigation of endothelial dysfunction in children with acute rheumatic fever
Author(s) -
Murat Çiftel,
Osman Yılmaz
Publication year - 2020
Publication title -
annals of pediatric cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.292
H-Index - 19
eISSN - 0974-2069
pISSN - 0974-5149
DOI - 10.4103/apc.apc_201_19
Subject(s) - medicine , endothelial dysfunction , cardiology , arterial stiffness , pathogenesis , body mass index , valvular heart disease , endothelium , heart disease , acute rheumatic fever , blood pressure
Acute rheumatic fever (ARF) is an important cause of valvular heart disease in children. Endothelial dysfunction plays an important role in the pathogenesis of valvular heart diseases. The role of endothelial dysfunction in valvular heart diseases due to ARF is not exactly known. In ARF, autoimmune injury, inflammation, oxidative stress, and impairment of nitric oxide in valvular endothelium may be the causes of endothelial dysfunction. The purpose of this study is to evaluate endothelial dysfunction and arterial stiffness in children with ARF.