Open AccessSingle nucleotide polymorphisms in runt-related transcription factor 2 and bone morphogenetic protein 2 impact on their maxillary and mandibular gene expression in different craniofacial patterns - A comparative study
Author(s) -
Rafaela Scariot,
Bernardo Olsson,
MateusJosé da Silva,
Camila Lago,
Robson Diego Calixto,
LucasAlexandre Ramazzotto,
NelsonLuis Barbosa Rebellato,
Christian Kirschneck,
FranciscoWanderley Garcia Paula-Silva,
ErikaCalvano Küchler
Publication year - 2021
Publication title -
annals of maxillofacial surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.365
H-Index - 6
ISSN - 2231-0746
DOI - 10.4103/ams.ams_40_21
Subject(s) - craniofacial , bone morphogenetic protein 2 , single nucleotide polymorphism , runx2 , maxilla , medicine , mandible (arthropod mouthpart) , dentistry , genetics , biology , gene expression , gene , genotype , botany , in vitro , genus
This study aimed to evaluate if single nucleotide polymorphisms (SNPs) in runt-related transcription factor 2 ( RUNX2 ) and bone morphogenetic protein 2 ( BMP2 ) are associated with different craniofacial patterns. Furthermore, we also investigated if RUNX2 and BMP2 expression in the maxilla and mandible are differently expressed according to facial phenotypes and influenced by the SNPs in their encoding genes. Orthognathic patients were included.