Open AccessHealer granules in nonhealing infected wounds
Author(s) -
Santosh Ashok Nandimath,
Rajkumar Garudanahally Chickklingaiah,
Viresh A. Nandimath,
Adwait Madhav Godse,
Bappaditya Mishra,
Shenbaga Seetha Priya
Publication year - 2018
Publication title -
annals of maxillofacial surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.365
H-Index - 6
ISSN - 2231-0746
DOI - 10.4103/ams.ams_35_18
Subject(s) - medicine , oral and maxillofacial surgery , antibiotics , metronidazole , head and neck , antibiotic prophylaxis , systemic antibiotics , surgery , incision and drainage , odontogenic infection , dermatology , abscess , odontogenic , pathology , microbiology and biotechnology , biology
Head-and-neck infection is one of the most frequently encountered issues in the field of oral and maxillofacial surgery. Most of the cases with head-and-neck infections are managed by empirical antibiotic therapy and extraction of offending infected tooth/teeth. However, long-term systemic antibiotic therapy can have profound compromising effects on host immune defense and thereby hamper healing, which, in turn, may lead to life-threatening complications such as localized septic foci or widespread septicemia at times leading to death of an individual. In this study, we are reviewing management of 15 cases with space infection in the maxillofacial region by local drug delivery with the help of collagen particles combined with mupirocin 2% w/w and metronidazole 1% w/w (BioFil-AB). We intend to study its efficacy in managing the space infections associated with extraoral infected wound as well as in preventing hazards of long-term systemic antibiotic therapy.