Open AccessCorrelation between the expression of matrix metalloproteinase-9, matrix metalloproteinase-13, tissue inhibitor of metalloproteinases-1, p16 and differentiation of head and neck squamous cell carcinoma: A prospective observational study
Author(s) -
Kapil Dev Soni,
Poonam Elhence,
Darwin Kaushal,
Nikhil Rajan,
Amit Goyal,
Bikram Choudhury,
Vidhu Sharma
Publication year - 2021
Publication title -
annals of maxillofacial surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.365
H-Index - 6
ISSN - 2231-0746
DOI - 10.4103/ams.ams_249_20
Subject(s) - medicine , perineural invasion , head and neck squamous cell carcinoma , metastasis , lymphovascular invasion , pathology , immunohistochemistry , matrix metalloproteinase , cancer , tissue microarray , oncology , population , head and neck cancer , environmental health
The expression of matrix metalloproteinase-9 (MMP-9), MMP-13, and tissue inhibitor of metalloproteinases (TIMP-1) in head and neck squamous cell carcinoma (HNSCC) could be a useful predictor of tumour differentiation, nodal metastasis, and invasiveness. We conducted this study to ascertain the correlation between the expression of these markers and differentiation of tumour cells.