Open AccessTherapeutic plasma exchange: A life-saving modality in Wegener's granulomatosis
Author(s) -
Archana Solanki,
Ashutosh Singh,
Abha Chauhan,
Tulika Chandra,
D Himanshu
Publication year - 2020
Publication title -
asian journal of transfusion science
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.262
H-Index - 22
eISSN - 1998-3565
pISSN - 0973-6247
DOI - 10.4103/ajts.ajts_89_19
Subject(s) - medicine , methylprednisolone , therapeutic plasma exchange , prednisolone , cyclophosphamide , immunosuppression , plasmapheresis , surgery , gastroenterology , chemotherapy , immunology , antibody
We report a case of Wegener's granulomatosis (WG) who very well responded to the combination strategy of therapeutic plasma exchange (TPE) and immunosuppression. The patient was a 38-year-old female, diagnosed with severe form of WG. A total of seven cycles was performed with 1.3 total plasma volumes (TPVs) on every alternate day. Standard induction therapy was also started that comprised of a combination of 500 mg intravenous (i.v.) cyclophosphamide and methylprednisolone 1 g slow i.v. daily for 3 days followed by oral prednisolone 60 mg daily for 4 weeks. After seven cycles of TPE, the patient improved and hence TPE was stopped.