Open AccessBlood group discrepancy in mixed-type autoimmune hemolytic anemia in a pediatric patient
Author(s) -
Minal Wasnik,
Saurabh Lahare,
Tushar Jagzape,
Ramesh Kumar Chandrakar
Publication year - 2021
Publication title -
asian journal of transfusion science
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.262
H-Index - 22
eISSN - 1998-3565
pISSN - 0973-6247
DOI - 10.4103/ajts.ajts_74_19
Subject(s) - autoimmune hemolytic anemia , autoantibody , medicine , antibody , immunology , anemia , cold agglutinin , red blood cell , coombs test , hemolytic anemia , hemoglobin , antigen , packed red blood cells , blood type (non human) , blood transfusion , abo blood group system
Autoimmune hemolytic anemia (AIHA) is characterized by the presence of antibodies directed against self-antigens on red blood cells (RBCs) leading to progressive RBC destruction along with reduced red cell survival. Mixed-type AIHA is characterized by the presence of both warm and cold-autoantibodies. These autoantibodies may cause blood-group discrepancy or cross-match incompatibility leading to delay in arranging suitable blood unit for transfusion. The detection of autoantibodies by monospecific-direct antiglobulin test showing positive reaction on immunoglobulin G and C3d and presence of cold-agglutinins leads to the diagnosis. We report a rare case of mixed AIHA in a 15 years female showing severe anemia, blood group discrepancy, and cross-match incompatibility. She received transfusion of least incompatible packed RBCs without any untoward effect.