Open AccessHereditary persistence of fetal hemoglobin
Author(s) -
Dharmesh Chandra Sharma,
Sachin Singhal,
Poonam Woike,
Sunita Rai,
Mahesh Yadav,
Rajesh Gaur
Publication year - 2020
Publication title -
asian journal of transfusion science
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.262
H-Index - 22
eISSN - 1998-3565
pISSN - 0973-6247
DOI - 10.4103/ajts.ajts_71_16
Subject(s) - fetal hemoglobin , medicine , hemoglobin , fetus , heterozygote advantage , persistence (discontinuity) , physiology , pregnancy , genetics , gene , biology , genotype , geotechnical engineering , engineering
Hereditary persistence of fetal hemoglobin (HPFH) is a benign condition in which significant fetal hemoglobin production continues well into adulthood, disregarding the normal shutoff point after which only adult-type hemoglobin should be produced. The percentage of incorrect expression might be as low as 10%-15% or as high as 100% of the total hemoglobin, usually higher in homozygotes than in heterozygotes. The present case is a typical example of homozygous HPFH.