Open AccessA study to assess the relationship between donor uric acid levels and supernatant hemolysis in stored packed red blood cell units
Author(s) -
Neerja Kushwaha,
HimanshuKumar Singh,
AmitKumar Biswas,
Joseph Philip,
Bhasker Mukherjee,
AjayK Baranwal
Publication year - 2022
Publication title -
asian journal of transfusion science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.262
H-Index - 22
eISSN - 1998-3565
pISSN - 0973-6247
DOI - 10.4103/ajts.ajts_61_21
Subject(s) - hemolysis , uric acid , medicine , mannitol , red blood cell , red cell , andrology , hemoglobin , packed red blood cells , biochemistry , immunology , chemistry , blood transfusion
Most of the red blood cell (RBC) storage lesions can be attributed to oxidative stress encountered by the RBCs throughout the duration of their storage. Various donor variables at the time of donation may be responsible for the total antioxidant capacity of the supernatant and thus, the "storability" and the magnitude of development of these RBC storage lesions. It is known that uric acid (UA) is responsible for more than 60% of the TAC of the blood. This study aims to explore the relationship between donor UA levels and the difference in percentage hemolysis, an important RBC storage lesion, on day 1 and day 21, in stored packed RBCs (PRBCs) units.