Open AccessCD4-positive lymphoepithelial-like carcinoma: Report of unusual case
Author(s) -
Luaay Aziz,
Raya Saab,
Toufic Eid,
Mousa A. AlAbbadi
Publication year - 2018
Publication title -
avicenna journal of medicine
Language(s) - English
Resource type - Journals
eISSN - 2249-4464
pISSN - 2231-0770
DOI - 10.4103/ajm.ajm_135_17
Subject(s) - pathology , immunostaining , cytokeratin , medicine , epstein–barr virus , submandibular gland , nasopharyngeal carcinoma , immunohistochemistry , virus , in situ hybridization , keratin , tumor cells , carcinoma , biology , cancer research , immunology , messenger rna , biochemistry , gene , radiation therapy
We are reporting an unusual case of lymphoepithelial-like carcinoma (LELC) in an 8-year-old female patient where the tumor cells showed unusual CD4 expression. The lesion was found in the left submandibular neck region, in the vicinity of the submandibular gland. The salivary gland was not infiltrated by the tumor, and the tumor exhibited a classic LELC with single and clusters of tumor cells surrounded by many hematolymphoid cells. The tumor cells revealed strong positivity for Epstein–Bar virus as confirmed by the EBER: Epstein-Barr Virus in situ hybridization (EBER-ISH) method of staining. Interestingly, the tumor cells expressed membranous immunostaining for the T-helper lymphocyte antibody (CD4) in addition to pan-cytokeratin. A brief discussion about this unusual finding is offered. The patient was treated as a case of Epstein–Bar virus-associated nasopharyngeal carcinoma with excellent response.