Open AccessStimulated by retinoic acid gene 8 (Stra8) plays important roles in many stages of spermatogenesis
Author(s) -
Haitao Ma,
Changmin Niu,
Jing Xia,
Xueyi Shen,
Mengmeng Xia,
Yanqiu Hu,
Ying Zheng
Publication year - 2018
Publication title -
asian journal of andrology/asian journal of andrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 74
eISSN - 1745-7262
pISSN - 1008-682X
DOI - 10.4103/aja.aja_26_18
Subject(s) - spermatogenesis , biology , retinoic acid , meiosis , gene , mechanism (biology) , homologous chromosome , sertoli cell , microbiology and biotechnology , genetics , endocrinology , philosophy , epistemology
To clarify the functions and mechanism of stimulated by retinoic acid gene 8 (Stra8) in spermatogenesis, we analyzed the testes from Stra8 knockout and wild-type mice during the first wave of spermatogenesis. Comparisons showed no significant differences in morphology and number of germ cells at 11 days postpartum, while 21 differentially expressed genes (DEGs) associated with spermatogenesis were identified. We speculate that Stra8 performs many functions in different phases of spermatogenesis, such as establishment of spermatogonial stem cells, spermatogonial proliferation and self-renewal, spermatogonial differentiation and meiosis, through direct or indirect regulation of these DEGs. We therefore established a preliminary regulatory network of Stra8 during spermatogenesis. These results will provide a theoretical basis for further research on the mechanism underlying the role of Stra8 in spermatogenesis.