Open AccessAlteration of mitochondrial function in oxidative stress in parkinsonian neurodegeneration: A cross-sectional study
Author(s) -
Rizwana Qadri,
Vinay Goyal,
Madhuri Behari,
Arulselvi Subramanian,
Sudip Kumar Datta,
Ayan Mukhopadhyay
Publication year - 2021
Publication title -
annals of indian academy of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 31
eISSN - 1998-3549
pISSN - 0972-2327
DOI - 10.4103/aian.aian_392_20
Subject(s) - oxidative stress , reactive oxygen species , neurodegeneration , medicine , parkinson's disease , cytochrome c oxidase , mitochondrion , oxidative phosphorylation , endocrinology , disease , biochemistry , chemistry
Appropriate mitochondrial function and oxidative balance are critical to neuronal survival. Accumulation of reactive oxygen species leads to oxidative stress that can cause free radical damage to biomolecules of the cell components and the molecules in the cellular milieu that eventually lead to a variety of chronic diseases including neurodegenerative disorders. Mitochondrial dysfunction initiates neuronal apoptosis thereby leading to neurodegenerative diseases including Parkinson's disease (PD).