Open AccessThe effect of Vitamin D administration on intracellular adhesion molecule-1 and vascular cell adhesion molecule-1 levels in hemodialysis patients: A placebo-controlled, double-blinded clinical trial
Author(s) -
Afsoon Emami Naeini,
Firouzeh Moeinzadeh,
Sahar Vahdat,
Aslan Ahmadi,
Zahra Parin Hedayati,
Safoora Shahzeidi
Publication year - 2017
Publication title -
journal of research in pharmacy practice
Language(s) - English
Resource type - Journals
eISSN - 2319-9644
pISSN - 2279-042X
DOI - 10.4103/2279-042x.200994
Subject(s) - medicine , placebo , hemodialysis , gastroenterology , cell adhesion molecule , intercellular adhesion molecule 1 , clinical trial , vcam 1 , vitamin , vitamin d and neurology , analysis of variance , inflammation , icam 1 , immunology , pathology , alternative medicine
Vitamin D deficiency is quite common among end-stage renal disease (ESRD) patients, and Vitamin D administration could reduce morbidity and mortality in these patients through different mechanisms. Cardiovascular diseases are the most common cause of mortality in these patients that are caused by vascular injuries. Intracellular adhesion molecule (ICAM) and vascular cell adhesion molecule (VCAM) are vascular inflammation indicators. The goal of this study is to find the effect of Vitamin D administration on ICAM-1 and VCAM-1 serum levels in ESRD patients on hemodialysis.